Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UL40
UPID:
ZN346_HUMAN
Alternative names:
Just another zinc finger protein
Alternative UPACC:
Q9UL40; B7Z367; Q68CV9; Q6ZMW1
Background:
Zinc finger protein 346, also known as Just another zinc finger protein, exhibits a unique binding affinity profile. It interacts with low affinity to double-stranded DNA (dsDNA) and single-stranded RNA (ssRNA), but demonstrates high affinity towards double-stranded RNA (dsRNA) without apparent sequence specificity. This protein is also speculated to bind specific microRNA (miRNA) hairpins, indicating a nuanced role in RNA-mediated cellular processes.
Therapeutic significance:
Understanding the role of Zinc finger protein 346 could open doors to potential therapeutic strategies. Its ability to interact with various RNA forms, including miRNAs, positions it as a key player in gene expression regulation and RNA metabolism, areas critical to disease pathogenesis and treatment.