Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UL45
UPID:
BL1S6_HUMAN
Alternative names:
Pallid protein homolog; Pallidin; Syntaxin 13-interacting protein
Alternative UPACC:
Q9UL45
Background:
Biogenesis of lysosome-related organelles complex 1 subunit 6, also known as Pallidin, plays a crucial role in the formation of lysosome-related organelles. It is a component of the BLOC-1 complex, essential for the biogenesis of platelet dense granules and melanosomes. This protein is involved in vesicle trafficking, particularly in docking and fusion processes, and is critical for neurite extension.
Therapeutic significance:
Pallidin's association with Hermansky-Pudlak syndrome 9, a disorder characterized by oculocutaneous albinism, bleeding, and lysosomal storage defects, highlights its potential as a therapeutic target. Understanding Pallidin's role could open doors to novel treatments for this syndrome.