Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9UL62
UPID:
TRPC5_HUMAN
Alternative names:
Transient receptor protein 5
Alternative UPACC:
Q9UL62; B2RP53; O75233; Q5JXY8; Q9Y514
Background:
Short transient receptor potential channel 5 (TRPC5) is a protein thought to form a receptor-activated non-selective calcium permeant cation channel. It is likely operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Additionally, TRPC5 has been shown to be calcium-selective and may be activated by intracellular calcium store depletion. It plays a crucial role in mediating calcium-dependent phosphatidylserine externalization and apoptosis in neurons through its association with PLSCR1.
Therapeutic significance:
Understanding the role of Short transient receptor potential channel 5 could open doors to potential therapeutic strategies.