Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UL68
UPID:
MYT1L_HUMAN
Alternative names:
-
Alternative UPACC:
Q9UL68; A7E2C7; B2RP54; Q6IQ17; Q9UPP6
Background:
Myelin transcription factor 1-like protein, encoded by the gene with accession number Q9UL68, is pivotal in neuronal differentiation. It represses non-neuronal genes during neuron differentiation and negative regulators of neurogenesis, such as the Notch signaling pathway. This protein's unique ability to repress multiple differentiation programs underscores its significance in neurodevelopment.
Therapeutic significance:
Linked to Intellectual developmental disorder, autosomal dominant 39, Myelin transcription factor 1-like protein's understanding could pave the way for innovative therapeutic strategies targeting neurodevelopmental disorders.