Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9ULC3
UPID:
RAB23_HUMAN
Alternative names:
-
Alternative UPACC:
Q9ULC3; B2R9I5; Q68DJ6; Q8NI06; Q9P023
Background:
Ras-related protein Rab-23 plays a pivotal role in intracellular membrane trafficking, influencing vesicle formation, movement, and fusion. It cycles between active and inactive states, engaging with various effectors to regulate processes such as autophagic vacuole assembly and pathogen defense. Rab-23's interaction with SUFU and GLI transcription factors underscores its significance in cellular signaling and development.
Therapeutic significance:
Carpenter syndrome 1, a disorder marked by skeletal, cardiac, and developmental anomalies, is linked to mutations in the gene encoding Rab-23. Understanding Rab-23's function could illuminate pathways for targeted therapies, offering hope for managing or correcting the multifaceted manifestations of this condition.