Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9ULD8
UPID:
KCNH3_HUMAN
Alternative names:
Brain-specific eag-like channel 1; Ether-a-go-go-like potassium channel 2; Voltage-gated potassium channel subunit Kv12.2
Alternative UPACC:
Q9ULD8; Q9UQ06
Background:
Potassium voltage-gated channel subfamily H member 3, known as Kv12.2, is a critical component of the nervous system. It functions as the pore-forming (alpha) subunit of voltage-gated potassium channels, facilitating fast inactivation and outward current flow. This channel's activity is influenced by cAMP levels and subunit assembly, indicating a complex regulation mechanism. Alternative names include Brain-specific eag-like channel 1 and Ether-a-go-go-like potassium channel 2.
Therapeutic significance:
Understanding the role of Potassium voltage-gated channel subfamily H member 3 could open doors to potential therapeutic strategies. Its pivotal function in neuronal excitability and signal transduction presents a promising target for modulating neurological functions and disorders.