Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9ULV4
UPID:
COR1C_HUMAN
Alternative names:
Coronin-3; hCRNN4
Alternative UPACC:
Q9ULV4; A7MAP0; A7MAP1; B3KU12; Q9NSK5
Background:
Coronin-1C, also known as Coronin-3 and hCRNN4, is pivotal in cell migration, cytoskeleton organization, and endosome fission. It regulates RAC1 activation, crucial for cell movement and cytoskeletal dynamics, including actin, microtubules, and vimentin filaments. Coronin-1C's role in endosome membrane fission is vital for cellular recycling and degradation processes. It also supports cell proliferation, migration, lamellipodia formation, and mitochondrial distribution.
Therapeutic significance:
Understanding the role of Coronin-1C could open doors to potential therapeutic strategies.