Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9UM19
UPID:
HPCL4_HUMAN
Alternative names:
-
Alternative UPACC:
Q9UM19; B2R5U2; D3DPU1; Q5TG97; Q8N611
Background:
Hippocalcin-like protein 4 plays a crucial role in the calcium-dependent regulation of rhodopsin phosphorylation. This process is vital for the proper functioning of visual processes, indicating the protein's significant role in sensory biology.
Therapeutic significance:
Understanding the role of Hippocalcin-like protein 4 could open doors to potential therapeutic strategies. Its involvement in the regulation of key sensory processes highlights its potential as a target for therapeutic intervention in sensory disorders.