Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9UNH7
UPID:
SNX6_HUMAN
Alternative names:
TRAF4-associated factor 2
Alternative UPACC:
Q9UNH7; C0H5W9; Q9Y449
Background:
Sorting nexin-6, alternatively known as TRAF4-associated factor 2, plays a crucial role in intracellular trafficking. It interacts with specific phosphatidylinositols, contributing to the retromer SNX-BAR subcomplex's function in retrograde transport from endosomes to the trans-Golgi network. This protein is essential for the recycling of cargo proteins and the regulation of lysosomal enzyme receptor IGF2R transport. Additionally, it influences E-cadherin sorting and EGFR degradation, highlighting its significance in cellular processes.
Therapeutic significance:
Understanding the role of Sorting nexin-6 could open doors to potential therapeutic strategies. Its involvement in critical cellular trafficking pathways and protein degradation processes suggests that modulating its activity could offer new avenues for treating diseases linked to these cellular functions.