Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9UNY4
UPID:
TTF2_HUMAN
Alternative names:
Lodestar homolog; RNA polymerase II termination factor; Transcription release factor 2
Alternative UPACC:
Q9UNY4; A8K4Q2; O75921; Q5T2K7; Q5VVU8; Q8N6I8
Background:
Transcription termination factor 2, also known as Lodestar homolog, plays a crucial role in transcription termination. It functions as a DsDNA-dependent ATPase, facilitating the removal of RNA polymerase II from the DNA template. This protein is also implicated in mitotic transcription repression and may have a role in pre-mRNA splicing.
Therapeutic significance:
Understanding the role of Transcription termination factor 2 could open doors to potential therapeutic strategies.