Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9UPT5
UPID:
EXOC7_HUMAN
Alternative names:
Exocyst complex component Exo70
Alternative UPACC:
Q9UPT5; B5MC69; B8XXP2; Q8ND93; Q8WV91; Q96FF0; Q9H8C3; Q9H9X3; Q9HA32
Background:
Exocyst complex component 7, also known as Exo70, is a pivotal protein in cellular processes, facilitating the docking of exocytic vesicles with fusion sites on the plasma membrane. Its role is crucial in insulin-stimulated glucose transporter SLC2A4 vesicle targeting to the plasma membrane in adipocytes and is essential for neuron survival and cortical development.
Therapeutic significance:
Exo70's involvement in the neurodevelopmental disorder with seizures and brain atrophy highlights its potential as a therapeutic target. Understanding the role of Exocyst complex component 7 could open doors to potential therapeutic strategies.