Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9UPZ3
UPID:
HPS5_HUMAN
Alternative names:
Alpha-integrin-binding protein 63; Hermansky-Pudlak syndrome 5 protein; Ruby-eye protein 2 homolog
Alternative UPACC:
Q9UPZ3; A8K6J8; A8K8S1; D3DQX9; D3DQY0; O95942; Q8N4U0
Background:
BLOC-2 complex member HPS5, also known as Alpha-integrin-binding protein 63, plays a crucial role in the regulation of lysosomes and specialized organelles like melanosomes and platelet dense granules. It is pivotal in intracellular vesicular trafficking in fibroblasts and may influence the general functions of integrins.
Therapeutic significance:
HPS5 is implicated in Hermansky-Pudlak syndrome 5, a disorder marked by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. Understanding the role of HPS5 could lead to novel therapeutic strategies for this syndrome.