Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9Y221
UPID:
NIP7_HUMAN
Alternative names:
KD93; Nucleolar pre-rRNA processing protein NIP7
Alternative UPACC:
Q9Y221; B2RD04; Q9NZZ0
Background:
The 60S ribosome subunit biogenesis protein NIP7 homolog, also known by its alternative names KD93 and Nucleolar pre-rRNA processing protein NIP7, plays a crucial role in cellular function. It is essential for the proper processing of 34S pre-rRNA and the assembly of the 60S ribosome subunit, a fundamental process for protein synthesis in all living cells.
Therapeutic significance:
Understanding the role of 60S ribosome subunit biogenesis protein NIP7 homolog could open doors to potential therapeutic strategies. Its pivotal function in ribosome assembly makes it a potential target for interventions in diseases where protein synthesis is disrupted.