Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y232
UPID:
CDYL_HUMAN
Alternative names:
Crotonyl-CoA hydratase
Alternative UPACC:
Q9Y232; A8K6D6; B4DLG4; Q0VDG7; Q32NC5; Q5VX99; Q6P7T5; Q9BWZ2; Q9Y424
Background:
Chromodomain Y-like protein, also known as Crotonyl-CoA hydratase, plays a pivotal role in epigenetic regulation. It binds specific histone marks, facilitating the transmission and restoration of repressive chromatin states. This protein is integral to the function of Polycomb repressive complex 2, enhancing its activity and ensuring the preservation of the epigenetic landscape. Additionally, it acts as a corepressor for REST, contributes to X chromosome inactivation, and is involved in DNA damage response and neuronal development.
Therapeutic significance:
Understanding the role of Chromodomain Y-like protein could open doors to potential therapeutic strategies.