Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9Y248
UPID:
PSF2_HUMAN
Alternative names:
GINS complex subunit 2
Alternative UPACC:
Q9Y248; D3DUM5; Q6IAG9
Background:
The DNA replication complex GINS protein PSF2, also known as GINS complex subunit 2, is pivotal for the GINS complex's correct functioning. This complex is crucial in initiating DNA replication and the progression of DNA replication forks. It is a core component of the CDC45-MCM-GINS (CMG) helicase, an essential molecular machine that unwinds template DNA during replication, forming the foundation around which the replisome is constructed.
Therapeutic significance:
Understanding the role of DNA replication complex GINS protein PSF2 could open doors to potential therapeutic strategies.