Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y286
UPID:
SIGL7_HUMAN
Alternative names:
Adhesion inhibitory receptor molecule 1; CDw328; D-siglec; QA79 membrane protein; p75
Alternative UPACC:
Q9Y286; Q9NZQ1; Q9UJ86; Q9UJ87; Q9Y502
Background:
Sialic acid-binding Ig-like lectin 7, known by alternative names such as Adhesion inhibitory receptor molecule 1 and CDw328, plays a crucial role in mediating sialic-acid dependent binding to cells. It has a preference for alpha-2,3- and alpha-2,6-linked sialic acid and interacts with disialogangliosides. This protein is involved in the immune response by acting as an inhibitory receptor, mediating inhibition of natural killer cells' cytotoxicity, and playing a role in hemopoiesis.
Therapeutic significance:
Understanding the role of Sialic acid-binding Ig-like lectin 7 could open doors to potential therapeutic strategies.