Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y2B2
UPID:
PIGL_HUMAN
Alternative names:
Phosphatidylinositol-glycan biosynthesis class L protein
Alternative UPACC:
Q9Y2B2; A8KA67; B4DYN4
Background:
The N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, also known as Phosphatidylinositol-glycan biosynthesis class L protein, plays a crucial role in the second step of GPI biosynthesis. This process is essential for the proper function and structure of various proteins.
Therapeutic significance:
Understanding the role of N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase could open doors to potential therapeutic strategies for Coloboma, congenital heart disease, ichthyosiform dermatosis, impaired intellectual development, and ear anomalies syndrome, a condition linked to mutations in the gene encoding this protein.