Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y2E5
UPID:
MA2B2_HUMAN
Alternative names:
Alpha-1,6-mannosidase; Mannosidase alpha class 2B member 2
Alternative UPACC:
Q9Y2E5; Q66MP2; Q86T67
Background:
Epididymis-specific alpha-mannosidase, also known as Alpha-1,6-mannosidase and Mannosidase alpha class 2B member 2, plays a crucial role in the processing of N-linked oligosaccharides during glycoprotein maturation. The precise mechanisms and pathways involving this enzyme underscore its importance in cellular functions and homeostasis.
Therapeutic significance:
Understanding the role of Epididymis-specific alpha-mannosidase could open doors to potential therapeutic strategies. Its involvement in glycoprotein processing suggests a broader implication in physiological and pathological conditions, making it a target of interest in drug discovery.