Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y2V2
UPID:
CHSP1_HUMAN
Alternative names:
Calcium-regulated heat-stable protein of 24 kDa
Alternative UPACC:
Q9Y2V2; B2R4C3; D3DUF5; Q2YDX5; Q9BQ53
Background:
Calcium-regulated heat-stable protein 1, also known as a 24 kDa protein, plays a crucial role in cellular processes by binding mRNA and regulating the stability of target mRNA. Its ability to bind single-stranded DNA (in vitro) further underscores its significance in cellular mechanisms. The protein's alternative names include Calcium-regulated heat-stable protein of 24 kDa, highlighting its stability and function in calcium-regulated processes.
Therapeutic significance:
Understanding the role of Calcium-regulated heat-stable protein 1 could open doors to potential therapeutic strategies. Its involvement in mRNA stability and DNA interactions suggests a foundational role in gene expression regulation, offering a promising avenue for therapeutic intervention in diseases where these processes are disrupted.