Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y2W2
UPID:
WBP11_HUMAN
Alternative names:
Npw38-binding protein; SH3 domain-binding protein SNP70; Splicing factor that interacts with PQBP-1 and PP1
Alternative UPACC:
Q9Y2W2; Q96AY8
Background:
WW domain-binding protein 11, also known as Npw38-binding protein, SH3 domain-binding protein SNP70, and Splicing factor that interacts with PQBP-1 and PP1, plays a crucial role in pre-mRNA splicing and may modulate PP1 phosphatase activity. Its involvement in multiple cellular processes underscores its importance in cellular function and regulation.
Therapeutic significance:
Linked to Vertebral, cardiac, tracheoesophageal, renal, and limb defects, a disorder with diverse manifestations, WW domain-binding protein 11's genetic variants offer insights into its pivotal role in disease pathology. Understanding its function could pave the way for innovative therapeutic approaches targeting these complex conditions.