Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9Y2X0
UPID:
MED16_HUMAN
Alternative names:
Mediator complex subunit 16; Thyroid hormone receptor-associated protein 5; Thyroid hormone receptor-associated protein complex 95 kDa component; Vitamin D3 receptor-interacting protein complex 92 kDa component
Alternative UPACC:
Q9Y2X0; Q6PJT2; Q96AD4; Q96I35; Q9Y652
Background:
Mediator of RNA polymerase II transcription subunit 16, also known as Mediator complex subunit 16, plays a pivotal role in the transcription of RNA polymerase II-dependent genes. It acts as a coactivator, facilitating the transfer of information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. This protein is essential for the assembly of a functional preinitiation complex, incorporating RNA polymerase II and general transcription factors.
Therapeutic significance:
Understanding the role of Mediator of RNA polymerase II transcription subunit 16 could open doors to potential therapeutic strategies.