Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y343
UPID:
SNX24_HUMAN
Alternative names:
-
Alternative UPACC:
Q9Y343; Q6UY33
Background:
Sorting nexin-24 plays a crucial role in intracellular trafficking, a process vital for cellular communication and nutrient transport. This protein, identified by its unique sequence Q9Y343, is essential for the proper distribution of cellular components.
Therapeutic significance:
Understanding the role of Sorting nexin-24 could open doors to potential therapeutic strategies. Its involvement in intracellular trafficking suggests its potential impact on numerous cellular processes and diseases.