Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9Y3B7
UPID:
RM11_HUMAN
Alternative names:
39S ribosomal protein L11, mitochondrial
Alternative UPACC:
Q9Y3B7; A6NLT0; A8K219; Q32P46; Q96Q73
Background:
The Large ribosomal subunit protein uL11m, also known as 39S ribosomal protein L11, mitochondrial, plays a crucial role in protein synthesis within mitochondria. Its involvement in the mitochondrial ribosome's structure and function underscores its importance in cellular energy production and homeostasis.
Therapeutic significance:
Understanding the role of Large ribosomal subunit protein uL11m could open doors to potential therapeutic strategies. Its pivotal function in mitochondrial protein synthesis makes it a target of interest for addressing mitochondrial disorders.