Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y3D5
UPID:
RT18C_HUMAN
Alternative names:
28S ribosomal protein S18-1, mitochondrial; 28S ribosomal protein S18c, mitochondrial; Small ribosomal subunit protein bS18c
Alternative UPACC:
Q9Y3D5
Background:
Small ribosomal subunit protein bS18m, also known as 28S ribosomal protein S18-1, mitochondrial, plays a crucial role in the mitochondrial ribosome. Its alternative names include 28S ribosomal protein S18c, mitochondrial, and Small ribosomal subunit protein bS18c, highlighting its significance in mitochondrial protein synthesis.
Therapeutic significance:
Understanding the role of Small ribosomal subunit protein bS18m could open doors to potential therapeutic strategies. Its pivotal function in mitochondrial protein synthesis makes it an intriguing target for research aimed at addressing mitochondrial disorders.