Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9Y4X3
UPID:
CCL27_HUMAN
Alternative names:
CC chemokine ILC; Cutaneous T-cell-attracting chemokine; ESkine; IL-11 R-alpha-locus chemokine; Skinkine; Small-inducible cytokine A27
Alternative UPACC:
Q9Y4X3
Background:
C-C motif chemokine 27, known by alternative names such as CC chemokine ILC, Cutaneous T-cell-attracting chemokine, and Skinkine, plays a pivotal role in the immune system. It acts as a chemotactic factor, specifically attracting skin-associated memory T-lymphocytes, and is crucial in mediating the homing of these cells to cutaneous sites through its binding to CCR10.
Therapeutic significance:
Understanding the role of C-C motif chemokine 27 could open doors to potential therapeutic strategies. Its unique function in directing the movement of T-lymphocytes to skin sites highlights its potential as a target in treating diseases with an immunological or inflammatory skin component.