Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y5G1
UPID:
PCDGF_HUMAN
Alternative names:
-
Alternative UPACC:
Q9Y5G1; A7E229; Q9Y5C7
Background:
Protocadherin gamma-B3, a potential calcium-dependent cell-adhesion protein, plays a crucial role in the establishment and maintenance of specific neuronal connections in the brain. Its unique function underscores its importance in neural circuitry and synaptic organization.
Therapeutic significance:
Understanding the role of Protocadherin gamma-B3 could open doors to potential therapeutic strategies. Its involvement in neuronal connections positions it as a key target for interventions in neurological disorders.