Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9Y5P8
UPID:
P2R3B_HUMAN
Alternative names:
PP2A subunit B isoform PR48; Protein phosphatase 2A 48 kDa regulatory subunit
Alternative UPACC:
Q9Y5P8; Q6P4G9; Q7RTT1; Q96H01
Background:
The Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta, also known as PP2A subunit B isoform PR48 and Protein phosphatase 2A 48 kDa regulatory subunit, plays a pivotal role in cellular function. It modulates substrate selectivity and catalytic activity of the phosphatase, directing its localization to specific subcellular compartments, thus influencing various cellular processes.
Therapeutic significance:
Understanding the role of Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta could open doors to potential therapeutic strategies. Its involvement in modulating key cellular processes highlights its potential as a target for drug discovery, aiming to regulate cellular functions and address various diseases.