Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y5U5
UPID:
TNR18_HUMAN
Alternative names:
Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein
Alternative UPACC:
Q9Y5U5; B1AME1; O95851; Q5U0I4; Q9NYJ9
Background:
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as the activation-inducible TNFR family receptor or glucocorticoid-induced TNFR-related protein, plays a pivotal role in immune regulation. It acts as a receptor for TNFSF18, facilitating interactions between activated T-lymphocytes and endothelial cells. This protein is crucial in regulating T-cell receptor-mediated cell death and activates NF-kappa-B via the TRAF2/NIK pathway.
Therapeutic significance:
Understanding the role of Tumor necrosis factor receptor superfamily member 18 could open doors to potential therapeutic strategies. Its involvement in T-cell regulation and NF-kappa-B activation positions it as a key target for modulating immune responses in various conditions.