Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y664
UPID:
KPTN_HUMAN
Alternative names:
Actin-associated protein 2E4
Alternative UPACC:
Q9Y664; B3KN86; B4DQ76; Q96GT1
Background:
The KICSTOR complex protein kaptin, also known as Actin-associated protein 2E4, plays a pivotal role in the amino acid-sensing branch of the TORC1 signaling pathway. It is essential for recruiting the GATOR1 complex to lysosomal membranes, facilitating its interaction with GATOR2 and the RAG GTPases, thereby regulating mTORC1 signaling in response to amino acid availability.
Therapeutic significance:
KICSTOR complex protein kaptin's involvement in Intellectual developmental disorder, autosomal recessive 41, underscores its potential as a therapeutic target. Understanding the role of KICSTOR complex protein kaptin could open doors to potential therapeutic strategies for treating developmental and cognitive impairments.