Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y692
UPID:
GMEB1_HUMAN
Alternative names:
DNA-binding protein p96PIF; Parvovirus initiation factor p96
Alternative UPACC:
Q9Y692; B1AT48; Q9NWH1; Q9UKD0
Background:
Glucocorticoid modulatory element-binding protein 1, also known as DNA-binding protein p96PIF and Parvovirus initiation factor p96, plays a pivotal role in cellular processes. It binds to glucocorticoid modulatory elements (GME) in the TAT promoter, enhancing sensitivity to glucocorticoids, and interacts with the transferrin receptor promoter. This protein is also an essential auxiliary factor for parvovirus replication.
Therapeutic significance:
Understanding the role of Glucocorticoid modulatory element-binding protein 1 could open doors to potential therapeutic strategies.