Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9Y6A1
UPID:
POMT1_HUMAN
Alternative names:
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Alternative UPACC:
Q9Y6A1; B3KQG0; B4DIF0; Q5JT01; Q5JT06; Q5JT08; Q8NC91; Q8TCA9; Q9NX32; Q9NX82; Q9UNT2
Background:
Protein O-mannosyl-transferase 1, also known as Dolichyl-phosphate-mannose--protein mannosyltransferase 1, plays a crucial role in transferring mannosyl residues to serine or threonine residues. This process requires the coexpression of POMT1 and POMT2 for enzyme activity, highlighting its specificity towards O-mannosylation of alpha-DAG1 and a select few proteins.
Therapeutic significance:
Linked to various forms of muscular dystrophy-dystroglycanopathy, including congenital forms with impaired intellectual development and limb-girdle types, understanding the role of Protein O-mannosyl-transferase 1 could open doors to potential therapeutic strategies for these debilitating conditions.